2025 Week 11 · Final
San Francisco 49ers at Arizona Cardinals, final 41–22
Pregame first read
ARI passing attack has the stronger league profile.
ARI passing attack #18/32 · SF pass defense #30/32 · 210 offense / 175 defense EPA plays.
Principal uncertainty · The model’s 80% range includes either team winning.
- Model spread
- PK
- Model total
- 47.5
- 80% range (ARI margin)
- -13.7 to +19.9
League profiles describe different prior opponents. They do not measure this game’s head-to-head outcome. The model is a historical scoring estimate, not a betting line, and it does not know injuries or availability.
Recorded leaders
- PassingJacoby BrissettARI452 pass yds
- RushingChristian McCaffreySF81 rush yds
- ReceivingMichael WilsonARI185 rec yds
Unit matchups
Rank among qualified teams by EPA per play, from each team's last five games before kickoff.
- ARI passing attack#18/32SF pass defense#30/32
- ARI run game#28/32SF run defense#26/32
- SF passing attack#12/32ARI pass defense#17/32
- SF run game#13/32ARI run defense#19/32
Players to watch
Per-game averages from 2025 games before kickoff, minimum two games. Availability is not verified.
SFSan Francisco 49ers
- Brock PurdyQB · 2 games293pass yds/g
- Christian McCaffreyRB · 10 games62.6rush yds/g
- Ricky PearsallWR · 4 games81.8rec yds/g
- Kendrick BourneWR · 9 games53.6rec yds/g
ARIArizona Cardinals
- Kyler MurrayQB · 5 games192pass yds/g
- Trey BensonRB · 4 games40rush yds/g
- Trey McBrideTE · 9 games67rec yds/g
- Marvin Harrison Jr.WR · 9 games58.3rec yds/g