2025 Week 3 · Final
Arizona Cardinals at San Francisco 49ers, final 15–16
Pregame first read
ARI run game has the stronger league profile.
ARI run game #5/32 · SF run defense #28/32 · 127 offense / 143 defense EPA plays.
Principal uncertainty · The model’s 80% range includes either team winning.
- Model spread
- ARI -4
- Model total
- 47.5
- 80% range (SF margin)
- -17.4 to +15.2
League profiles describe different prior opponents. They do not measure this game’s head-to-head outcome. The model is a historical scoring estimate, not a betting line, and it does not know injuries or availability.
Recorded leaders
- PassingMac JonesSF284 pass yds
- RushingChristian McCaffreySF52 rush yds
- ReceivingRicky PearsallSF117 rec yds
Unit matchups
Rank among qualified teams by EPA per play, from each team's last five games before kickoff.
- SF passing attack#6/32ARI pass defense#11/32
- SF run game#22/32ARI run defense#20/32
- ARI passing attack#11/32SF pass defense#18/32
- ARI run game#5/32SF run defense#28/32
Players to watch
Per-game averages from 2025 games before kickoff, minimum two games. Availability is not verified.
ARIArizona Cardinals
- Kyler MurrayQB · 2 games192pass yds/g
- Trey BensonRB · 2 games41.5rush yds/g
- Trey McBrideTE · 2 games69.5rec yds/g
- Marvin Harrison Jr.WR · 2 games49rec yds/g
SFSan Francisco 49ers
- Christian McCaffreyRB · 2 games62rush yds/g
- Ricky PearsallWR · 2 games82rec yds/g
- Jauan JenningsWR · 2 games52.5rec yds/g